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Homepage > Centers > Merry L. Lindsey, Ph.D.
NHLBI Proteomics Administrative and Coordination Center

UT Health Science Center at San Antonio Cardiovascular Proteomics Center: Merry L. Lindsey, Ph.D.

  Merry Lindsey, PhD, FAHA2, FAPS
Director, Jackson Center for Heart Research
University of Mississippi Medical Center
Department of Physiology & Biophysics
mllindsey@umc.edu 
  Co-PI
Richard A. Lange, MD, MBA
Professor & Executive Vice Chair of Medicine
University of Texas Health Science Center at San Antonio
Department of Medicine
langera@uthscsa.edu

Our center is dedicated to performing cardiovascular research that involves:

Developing multidimensional approaches to examine the mechanisms whereby the left ventricle responds to injury;
Applying the knowledge gained to develop therapeutic strategies to prevent, slow, or reverse the progression to heart failure;
Disseminating our results to the general, scientific, and medical communities.

The Key Investigators

Seema Ahuja, M.D. ahuja@uthscsa.edu
Robert J. Chilton, DO chilton@uthscsa.edu
Youn-Min Chou, Ph.D. younmin.chou@utsa.edu
John M. Erikson, MD, Ph.D. erikson@uthscsa.edu
Gregg B. Fields, Ph.D. gfields@tpims.org
Hai-Chao Han, Ph.D. haichao.han@utsa.edu
Yufang Jin, Ph.D. yufang.jin@utsa.edu
Susan T. Weintraub, Ph.D. weintraub@uthscsa.edu

Selected Recent Publications

Matrix Metalloproteinase (MMP)-9: A proximal biomarker for cardiac remodeling and a distal biomarker for inflammation. Halade GV, Jin YF, Lindsey ML. Pharmacol Ther. 2013 Apr 2. doi:pii: S0163-7258(13)00078-8. 10.1016/j.pharmthera.2013.03.009. [Epub ahead of print] PMID: 23562601 [PubMed - as supplied by publisher]

Using proteomics to uncover extracellular matrix interactions during cardiac remodeling. Patterson NL, Iyer RP, Bras LD, Li Y, Andrews TG, Aune GJ, Lange RA, Lindsey ML. Proteomics Clin Appl. 2013 Mar 27. doi: 10.1002/prca.201200100. [Epub ahead of print] PMID: 23532927 [PubMed - as supplied by publisher]

Left Ventricular Remodeling: One Small Step for the Extracellular Matrix Will Translate to a Giant Leap for the Myocardium. Yabluchanskiy A, Chilton RJ, Lindsey ML. Congest Heart Fail. 2013 Jan 25. doi: 10.1111/chf.12023. [Epub ahead of print] No abstract available. PMID: 23350683 [PubMed - as supplied by publisher]

Matrix metalloproteinases: drug targets for myocardial infarction. Yabluchanskiy A, Li Y, Chilton RJ, Lindsey ML. Curr Drug Targets. 2013 Mar;14(3):276-86. PMID: 23316962 [PubMed - in process]

Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation. Ma Y, Halade GV, Zhang J, Ramirez TA, Levin D, Voorhees A, Jin YF, Han HC, Manicone AM, Lindsey ML. Circ Res. 2013 Feb 15;112(4):675-88. doi: 10.1161/CIRCRESAHA.111.300502. Epub 2012 Dec 20. PMID: 23261783 [PubMed - in process]

Selected Recent Publications Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury. Yoshioka J, Chutkow WA, Lee S, Kim JB, Yan J, Tian R, Lindsey ML, Feener EP, Seidman CE, Seidman JG, Lee RT. J Clin Invest. 2012 Jan 3;122(1):267-79. doi: 10.1172/JCI44927. Epub 2011 Dec 27. PMID: 22201682 PMCID: PMC3248280

Matrix metalloproteinase-28 deletion amplifies inflammatory and extracellular matrix responses to cardiac aging. Ma Y, Chiao YA, Zhang J, Manicone AM, Jin YF, Lindsey ML. Microsc Microanal. 2012 Feb;18(1):81-90. Epub 2011 Dec 8. PMID: 22153350

Roles of saturated vs. polyunsaturated fat in heart failure survival: not all fats are created equal. Halade GV, Jin YF, Lindsey ML. Cardiovasc Res. 2012 Jan 1;93(1):4-5. Epub 2011 Nov 8. PMID: 22068160 PMCID: PMC3243043 [Available on 2013/1/1]

Introduction: Extracellular matrix and cardiovascular remodeling-using microscopy to delineate mechanisms. Lindsey ML, Borg TK. Microsc Microanal. 2012 Feb;18(1):1-2. PMID: 22258720

Extracellular matrix proteomics in cardiac ischemia/reperfusion: the search is on. Deleon KY, de Castro Brás LE, Lange RA, Lindsey ML. Circulation. 2012 Feb 14;125(6):746-8. Epub 2012 Jan 18. PMID: 22261193 PMCID: PMC3289097 [Available on 2013/2/14]

Using extracellular matrix proteomics to understand left ventricular remodeling. Lindsey ML, Weintraub ST, Lange RA. Circ Cardiovasc Genet. 2012 Feb 1;5(1):o1-7. PMID: 22337931 PMCID: PMC3282021 [Available on 2013/2/1]

Heart rate reduction: an old and novel candidate heart failure therapy. Ma Y, Chilton RJ, Lindsey ML. Hypertension. 2012 May;59(5):908-10. Epub 2012 Apr 9. PMID: 22493078

Women are different: the role of coupling factor 6 in blood pressure regulation. de Castro Brás LE, DeLeon KY, Lindsey ML. Hypertens Res. 2012 May;35(5):485-6. doi: 10.1038/hr.2012.9. Epub 2012 Feb 2. PMID: 22297476 [PubMed - in process]

Plasma Fractionation Enriches Post-Myocardial Infarction Samples Prior to Proteomics Analysis. de Castro Brás LE, Deleon KY, Ma Y, Dai Q, Hakala K, Weintraub ST, Lindsey ML. Int J Proteomics. 2012;2012:397103. Epub 2012 Jun 18. PMID: 22778955 PMCID: PMC3385641

Structural basis for matrix metalloproteinase 1-catalyzed collagenolysis. Bertini I, Fragai M, Luchinat C, Melikian M, Toccafondi M, Lauer JL, Fields GB. J Am Chem Soc. 2012 Feb 1;134(4):2100-10. Epub 2012 Jan 19. PMID: 22239621 PMCID: PMC3298817 [Available on 2013/2/1]

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