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Homepage > Centers > Alexander Kurosky, Ph.D.
NHLBI Proteomics Administrative and Coordination Center

The University of Texas Medical Branch NHLBI Proteomics Center at Galveston: Alexander Kurosky, Ph.D.

Alexander Kurosky

Alexander Kurosky, Ph.D.
Director, UTMB NHLBI Proteomics Center on Airway Inflammation
Professor, Biochemistry and Molecular Biology
Director, UTMB Biomolecular Resource Facility
Senior Scientist, Sealy Center for Molecular Medicine

The UTMB NHLBI Proteomics Center is pursuing both proteomics technology development and directed proteomics research to investigate total protein expression in order to obtain a more global understanding of biological phenomena. The overall theme of this Center is airway inflammation focusing on asthma, allergy, and respiratory viruses.


The Key Investigators

Allan Brasier, M.D. Associate Center Director
A. Kurosky, PhD & J. Wiktorowicz, Ph.D. Leaders Team 1: Innovative Methods Development
D. Gorenstein, Ph.D. Leaders Team 2: Array-Based Technologies
A. Brasier, MD & Y. Zhao, Ph.D. Leaders Team 3: Protein Complexes & Signaling in Lung Mucosal Cells
A. Kurosky, PhD & K. Pazdrak, MD, Ph.D. Leaders Team 4: Leukocytes in Airway Inflammation
S. Sur, MD & I. Boldogh, Ph.D. Leaders Team 5: Oxidative Stress in Asthma/ COPD
A. Brasier, MD & W. Calhoun, M.D. Leaders Team 6: Molecular Phenotypes in Asthma/COPD
R. Garofalo, MD & A. Casola, M.D. Leaders Team 7: Oxidative Lung Injury in Respiratory Viral Infections
M. Massoud, Ph.D. Leader Core A: Dynamic Cell & Tissue Imaging
B. Luxon, Ph.D. Leader Core B: Informatics/Bioinformatics
K. Rosenblatt, M.D., Ph.D. Leader Core C: Biomarker Verification

Selected Recent Publications

Model studies on iTRAQ modification of peptides: sequence-dependent reaction specificity. Wiktorowicz JE, English RD, Wu Z, Kurosky A. J Proteome Res. 2012 Mar 2;11(3):1512-20. Epub 2012 Feb 15. PMID: 22335824 PMCID: PMC3310887 [Available on 2013/3/2]

Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine. Boldogh I, Hajas G, Aguilera-Aguirre L, Hegde ML, Radak Z, Bacsi A, Sur S, Hazra TK, Mitra S. J Biol Chem. 2012 Jun 15;287(25):20769-73. Epub 2012 May 8. PMID: 22568941 [PubMed - in process] PMCID: PMC3375501 [Available on 2013/6/15]

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome. Mandal SM, Hegde ML, Chatterjee A, Hegde PM, Szczesny B, Banerjee D, Boldogh I, Gao R, Falkenberg M, Gustafsson CM, Sarkar PS, Hazra TK. J Biol Chem. 2012 Jan 20;287(4):2819-29. Epub 2011 Nov 30. PMID: 22130663 PMCID: PMC3268439 [Available on 2013/1/20]

High throughput short interfering RNA (siRNA) screening of the human kinome identifies novel kinases controlling the canonical nuclear factor-κB (NF-κB) activation pathway. Choudhary S, Rosenblatt KP, Fang L, Tian B, Wu ZH, Brasier AR. J Biol Chem. 2011 Oct 28;286(43):37187-95. Epub 2011 Sep 7. PMID: 21900239 [PubMed - indexed for MEDLINE] PMCID: PMC3199466 [Available on 2012/10/28]

Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. Savidge TC, Urvil P, Oezguen N, Ali K, Choudhury A, Acharya V, Pinchuk I, Torres AG, English RD, Wiktorowicz JE, Loeffelholz M, Kumar R, Shi L, Nie W, Braun W, Herman B, Hausladen A, Feng H, Stamler JS, Pothoulakis C. Nat Med. 2011 Aug 21;17(9):1136-41. doi: 10.1038/nm.2405. PMID: 21857653 PMCID: PMC3277400

Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin. Pazdrak K, Young TW, Straub C, Stafford S, Kurosky A. J Immunol. 2011 Jun 1;186(11):6485-96. Epub 2011 Apr 27. PMID: 21525390 PMCID: PMC3100773

Viral-mediated inhibition of antioxidant enzymes contributes to the pathogenesis of severe respiratory syncytial virus bronchiolitis. Hosakote YM, Jantzi PD, Esham DL, Spratt H, Kurosky A, Casola A, Garofalo RP. Am J Respir Crit Care Med. 2011 Jun 1;183(11):1550-60. Epub 2011 Mar 4. PMID: 21471094 PMC3137144

Quantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studies. Wiktorowicz JE, Stafford S, Rea H, Urvil P, Soman K, Kurosky A, Perez-Polo JR, Savidge TC. Biochemistry. 2011 Jun 28;50(25):5601-14. Epub 2011 Jun 7. PMID: 21615140 PMCID: PMC3133729

Quantification of activated NF-kappaB/RelA complexes using ssDNA aptamer affinity-stable isotope dilution-selected reaction monitoring-mass spectrometry. Zhao Y, Widen SG, Jamaluddin M, Tian B, Wood TG, Edeh CB, Brasier AR. Mol Cell Proteomics. 2011 Jun;10(6):M111.008771. Epub 2011 Apr 18. PMID: 21502374 PMCID: PMC3108844
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