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Homepage > Centers > Jennifer E. Van Eyk, Ph.D.
NHLBI Proteomics Administrative and Coordination Center

The Johns Hopkins University Proteomic Innovation Center in Heart Failure: Jennifer E. Van Eyk, Ph.D.

Jennifer E. Van Eyk

Jennifer E. Van Eyk, Ph.D.
Professor of Medicine, Biological Chemistry and Biomedical Engineering, Johns Hopkins University
Director, Hopkins NHLBI Proteomics Innovation Group and the JHU Bayview Proteomics Center.

The central philosophy of the Johns Hopkins Proteomic Innovation Center is that innovative technologies in proteomics will be essential to pursue compelling biological and clinical questions. The highly collaborative and integrated nature of our investigator team allows us to keep focused on clinically-relevant problems and provide rapid paths to translational medicine.


The Key Investigators

Anne Murphy, M.D.
Dept. Pediatrics, School of Medicine, Co-PI
Robert Cole, Ph.D. Dept. Biological Chemistry, School of Medicine
Josef Coresh, M.D., Ph.D Dept. Epidemiology, School of Public Health
Robert Cotter, Ph.D Dept. Pharmacology and Mol. Sciences, School of Medicine
David Graham, Ph.D. Dept. Mol. and Comp. Pathobiology, School of Medicine
Jerry Hart, Ph.D. Dept. Biological Chemistry, School of Medicine
David Kass, M.D. Dept. Medicine, School of Medicine
Edgar Miller, M.D., Ph.D.
Dept. Medicine, School of Medicine
Brian O’Rourke,Ph.D. Dept. Medicine, School of Medicine
Akhilesh Pandey, M.D., Ph.D Institute of Genetic Medicine, School of Medicine
Gregg Semenza, M.D., Ph.D Dept. Pediatrics, School of Medicine
Hui Zhang, Ph.D. Dept. Pathology, School of Medicine

Selected Recent Publications

Constrained selected reaction monitoring: Quantification of selected post-translational modifications and protein isoforms. Liu X, Jin Z, O'Brien R, Bathon J, Dietz HC, Grote E, Van Eyk JE. Methods. 2013 Mar 22. doi:pii: S1046-2023(13)00075-3. PMID: 23523700 [PubMed - as supplied by publisher]

A fast and reproducible method for albumin isolation and depletion from serum and cerebrospinal fluid. Holewinski RJ, Jin Z, Powell MJ, Maust MD, Van Eyk JE. Proteomics. 2013 Mar;13(5):743-50. doi: 10.1002/pmic.201200192. PMID: 23300121 [PubMed - in process]

Troponin I alterations detected by multiple-reaction monitoring: how might this impact the study of heart failure? Kirk JA, Zhang P, Murphy AM, Van Eyk JE. Expert Rev Proteomics. 2013 Feb;10(1):5-8. doi: 10.1586/epr.12.77. PMID: 23414352 [PubMed - in process]

Redox regulation of mitochondrial ATP synthase. Wang SB, Murray CI, Chung HS, Van Eyk JE. Trends Cardiovasc Med. 2013 Jan;23(1):14-8. doi: 10.1016/j.tcm.2012.08.005. PMID: 23312134 [PubMed - in process]

Improved protein extractionand protein identification from archival formalin-fixed paraffin-embedded human aortas. Fu Z, Yan K, Rosenberg A, Jin Z, Crain B, Athas G, Heide RS, Howard T, Everett AD, Herrington D, Van Eyk JE. Proteomics Clin Appl. 2013 Jan 21. doi: 10.1002/prca.201200064. PMID: 23339088 [PubMed - as supplied by publisher]

Cysteine oxidative posttranslational modifications: emerging regulation in the cardiovascular system. Chung HS, Wang SB, Venkatraman V, Murray CI, Van Eyk JE. Circ Res. 2013 Jan 18;112(2):382-92. doi: 10.1161/CIRCRESAHA.112.268680. PMID: 23329793 [PubMed - indexed for MEDLINE] 

The human proteome - a scientific opportunity for transforming diagnostics, therapeutics, and healthcare. Vidal M, Chan DW, Gerstein M, Mann M, Omenn GS, Tagle D, Sechi S; Workshop Participants. Clin Proteomics. 2012 Jul 3;9(1):6. PMID: 22583803 PMCID: PMC3388576

Regulation of lipid metabolism by dicer revealed through SILAC mice. Huang TC, Sahasrabuddhe NA, Kim MS, Getnet D, Yang Y, Peterson JM, Ghosh B, Chaerkady R, Leach SD, Marchionni L, Wong GW, Pandey A. J Proteome Res. 2012 Apr 6;11(4):2193-205. Epub 2012 Feb 28. PMID: 22313051 [PubMed - in process]

Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Alfaro JF, Gong CX, Monroe ME, Aldrich JT, Clauss TR, Purvine SO, Wang Z, Camp DG 2nd, Shabanowitz J, Stanley P, Hart GW, Hunt DF, Yang F, Smith RD. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7280-5. Epub 2012 Apr 19. PMID: 22517741 [PubMed - in process] PMCID: PMC3358849 [Available on 2012/11/8]

Evidence of the Involvement of O-GlcNAc-modified Human RNA Polymerase II CTD in Transcription in Vitro and in Vivo. Ranuncolo SM, Ghosh S, Hanover JA, Hart GW, Lewis BA. J Biol Chem. 2012 Jul 6;287(28):23549-61. Epub 2012 May 17. PMID: 22605332 [PubMed - in process] PMCID: PMC3390630 [Available on 2013/7/6]

Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Tarrant MK, Rho HS, Xie Z, Jiang YL, Gross C, Culhane JC, Yan G, Qian J, Ichikawa Y, Matsuoka T, Zachara N, Etzkorn FA, Hart GW, Jeong JS, Blackshaw S, Zhu H, Cole PA. Nat Chem Biol. 2012 Jan 22;8(3):262-9. doi: 10.1038/nchembio.771. PMID: 22267120 PMCID: PMC3288285 [Available on 2012/9/1]

A Cell Surfaceome Map for Immunophenotyping and Sorting Pluripotent Stem Cells. Gundry RL, Riordon DR, Tarasova Y, Chuppa S, Bhattacharya S, Juhasz O, Wiedemeier O, Milanovich S, Noto FK, Tchernyshyov I, Raginski K, Bausch-Fluck D, Tae HJ, Marshall S, Duncan SA, Wollscheid B, Wersto RP, Rao S, Van Eyk JE, Boheler KR. Mol Cell Proteomics. 2012 Apr 6. [Epub ahead of print] PMID: 22493178 [PubMed - as supplied by publisher]

Pathological Cardiac Hypertrophy Alters Intracellular Targeting of PDE5 from Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling. Zhang M, Takimoto E, Lee DI, Santos CX, Nakamura T, Hsu S, Jiang A, Nagayama T, Bedja D, Yuan Y, Eaton P, Shah AM, Kass DA. Circulation. 2012 Jul 24. [Epub ahead of print] PMID: 22829024 [PubMed - as supplied by publisher]

Divide and conquer: the application of organelle proteomics to heart failure. Agnetti G, Husberg C, Van Eyk JE. Circ Res. 2011 Feb 18;108(4):512-26. PMID: 21335433

Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study. Giles JT, Fert-Bober J, Park JK, Bingham CO 3rd, Andrade F, Fox-Talbot K, Pappas D, Rosen A, van Eyk J, Bathon JM, Halushka MK.Arthritis Res Ther. 2012 Feb 24;14(1):R39. PMID: 22364592 [PubMed - in process] PMCID: PMC3392839

Dephosphorylation of cardiac proteins in vitro - a matter of phosphatase specificity. Husberg C, Agnetti G, Holewinski RJ, Christensen G, Van Eyk JE. Proteomics. 2012 Apr;12(7):973-8. doi: 10.1002/pmic.201100116. PMID: 22522803 [PubMed - in process]

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