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NHLBI Proteomics Administrative and Coordination Center

Harvard - Broad Proteomics Center: Robert Gerszten, M.D.

Robert Gerszten

Robert Gerszten, M.D.
Director, Translational Research in the Cardiology Division
Director, Harvard – Broad Proteomics Center
Associate Professor of Medicine, Harvard Medical School

The overall goal of our Center is to identify novel pathways and biomarkers of ischemic heart disease. Our Center's approach integrates three core components: 1) Proteomic Technology Development, led by Dr. Steven Carr (Broad Institute); 2) Molecular Mechanistic and Functional Studies, led by Drs. Anthony Rosenzweig and Robert Gerszten; and 3) Application of Proteomics Approaches to Clinical Questions, led by Drs. Marc Sabatine and Robert Gerszten. The overall goal is to identify new metabolites and proteins that mark disease activity, shed insight into disease progression, and ultimately provide targets for therapeutic intervention.


Steven Carr, Ph.D. Broad Institute
Anthony Rosenzweig, M.D. Beth Israel Deaconess Medical Center
Marc S. Sabatine, M.D., M.P.H. Brigham & Women's Hospital

Key Investigators

Gregory Lewis, M.D. Massachusetts General Hospital
Michelle O’DOnoghue, M.D. Brigham & Women's Hospital


Selected Recent Publications

Metabolite Profiling Identifies a Branched Chain Amino Acid Signature in Acute Cardioembolic Stroke. Kimberly WT, Wang Y, Pham L, Furie KL, Gerszten RE. Stroke. 2013 Mar 21. PMID: 23520238 [PubMed - as supplied by publisher]

Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry. Gillette MA, Carr SA. Nat Methods. 2013 Jan;10(1):28-34. PMID: 23269374 [PubMed - in process]

Refined Preparation and Use of Anti-diglycine Remnant (K-{varepsilon}-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. Epub 2012 Dec 24. PMID: 23266961 [PubMed - in process]

Metalloenzymes: Put a ring on it. Rosenzweig AC. Nat Chem Biol. 2013 Apr;9(4):220-1. PMID: 23508187 [PubMed - in process]

Genome mining for methanobactins. Kenney GE, Rosenzweig AC. BMC Biol. 2013 Feb 26;11(1):17. PMID: 23442874 [PubMed - as supplied by publisher]

Prospective evaluation of pregnancy-associated plasma protein-a and outcomes in patients with acute coronary syndromes. Bonaca MP, Scirica BM, Sabatine MS, Jarolim P, Murphy SA, Chamberlin JS, Rhodes DW, Southwick PC, Braunwald E, Morrow DA. J Am Coll Cardiol. 2012 Jul 24;60(4):332-8. PMID: 22813612 [PubMed - in process]

Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. Epub 2012 Apr 14. PMID: 22505724 [PubMed - in process]

iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mertins P, Udeshi ND, Clauser KR, Mani DR, Patel J, Ong SE, Jaffe JD, Carr SA. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423. Epub 2011 Dec 30.

Diagnostic evaluation of the MRP-8/14 for the emergency assessment of chest pain. Vora AN, Bonaca MP, Ruff CT, Jarolim P, Murphy S, Croce K, Sabatine MS, Simon DI, Morrow DA. J Thromb Thrombolysis. 2012 Aug;34(2):229-34. PMID: 22446997 [PubMed - in process]

The human proteome - a scientific opportunity for transforming diagnostics, therapeutics, and healthcare. Vidal M, Chan DW, Gerstein M, Mann M, Omenn GS, Tagle D, Sechi S; Workshop Participants. Clin Proteomics. 2012 Jul 3;9(1):6. PMID: 22583803 [PubMed - as supplied by publisher] PMCID: PMC3388576

Interlaboratory evaluation of automated, multiplexed peptide immunoaffinity enrichment coupled to multiple reaction monitoring mass spectrometry for quantifying proteins in plasma. Kuhn E, Whiteaker JR, Mani DR, Jackson AM, Zhao L, Pope ME, Smith D, Rivera KD, Anderson NL, Skates SJ, Pearson TW, Paulovich AG, Carr SA. Mol Cell Proteomics. 2012 Jun;11(6):M111.013854. Epub 2011 Dec 22. PMID: 22199228 [PubMed - in process]

Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study. Turer AT, Addo TA, Martin JL, Sabatine MS, Lewis GD, Gerszten RE, Keeley EC, Cigarroa JE, Lange RA, Hillis LD, de Lemos JA. J Am Coll Cardiol. 2011 Jun 14;57(24):2398-405. PMID: 21658559 PMCID: PMC3130506

A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease. Addona TA, Shi X, Keshishian H, Mani DR, Burgess M, Gillette MA, Clauser KR, Shen D, Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, Carr SA. Nat Biotechnol. 2011 Jun 19;29(7):635-43. doi: 10.1038/nbt.1899. PMID: 21685905 PMCID: PMC3366591

Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics. Gerszten RE, Asnani A, Carr SA. Circ Res. 2011 Aug 5;109(4):463-74. PMID: 21817166

Early dynamic risk stratification with baseline troponin levels and 90-minute ST-segment resolution to predict 30-day cardiovascular mortality in ST-segment elevation myocardial infarction: analysis from CLopidogrel as Adjunctive ReperfusIon TherapY (CLARITY)-Thrombolysis in Myocardial Infarction (TIMI) 28. Sherwood MW, Morrow DA, Scirica BM, Jiang S, Bode C, Rifai N, Gerszten RE, Gibson CM, Cannon CP, Braunwald E, Sabatine MS. Am Heart J. 2010 Jun;159(6):964-971.e1. PMID: 20569707 PMCID: PMC2892399

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